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We found that knockdown of components of the core Fe-S cluster biosynthetic complex diminished Fe-S protein function and prolonged survival of H1299 and PC9 cells starved of cystine (Fig

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Finally, immunofluorescence imaging in BEAS-2B, A549, and H1299 cells revealed co-localization of SLC25A39 protein (green fluorescence) with MitoTracker (red fluorescence), confirming mitochondrial localization and elevated expression in LUAD cell lines (Fig

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Particularly, how to precisely maintain its protective concentration in the central nervous system without inducing bilirubin neurotoxicity is a core issue for future studies