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Studies over the past decade have emphasized HIF-1 as the central regulator of tumor cell survival, proliferation, angiogenesis, and metastasis under graded oxygen tension (Schofield and Ratcliffe, 2004)

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Biopreserv Biobank 21(2):121141 Barberino RS, Lins TLB, Monte AP, Gouveia BB, Campinho DS, Palheta RC Jr, Smitz JE, Matos MHT (2022) Melatonin attenuates cyclophosphamide-induced primordial follicle loss by interaction with MT1 receptor and modulation of PTEN/Akt/FOXO3a proteins in the mouse ovary