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The resultant ferroptotic death selectively depletes the most functionally active T cells, thereby dismantling the immune response at its peak and blunting the effectiveness of immunotherapies like checkpoint inhibitors, which depend on the persistence of robust TIL populations

25, 17861795.10.1161/01.ATV.0000178169.95781.49 84 MoritaT.MitsialisS

Jinsong Z, Fengtong H et al (2020) Expert consensus on the diagnosis and treatment of acute diquat poisoning

Neoplastic EXOs have been reported to contain an elevated miRNA content, suppress T-cell division and transformation, and trigger apoptosis via the FasL and MARK1 pathways, hence enhancing the tumors ability to fight against immune-mediated responses ( Fabbri et al