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Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations

91.4% pts Stage 2 or 3 ( 62% Stage 3) BMI: 33

J Clin Invest 97: 28722877 [DOI] [PMC free article] [PubMed] [Google Scholar] Liu C., Park M., Tsao M.S

Under oxidative stress, a shift in serine-dependent 1C metabolism occurs from methylation to transsulfuration, leading to the condensation of serine with homocysteine to generate cysteine, thus enhancing GSH synthesis [55, 56] (see Fig