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Conversely, with conditions leading to neurodegeneration or chronic inflammation, oxidative stress persists long enough to lead to abnormal immune response pathwaysparticularly NF-kband prolonged treatment with GSH may lead to reduced redox tone and thus attenuating NF-kB, causing an anti-inflammatory response instead of an immuno-supportive one (Limongi et al., 2019

The accumulation of calcium ions within cells can potentially induce the release of Cytochrome C (CytC) in mitochondria, which activates caspase-9 and the final executor protein caspase-3

This protein is responsible for reabsorbing glucose back into the bloodstream, but SGLT2 inhibitors prevent this from happening, resulting in increased glucose excretion in the urine, which improves glycemic control in people with T2DM

They are less toxic, biodegradable, and offer antioxidant, anti-inflammatory, and antimicrobial properties

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