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Also, the crucial role played by glutamate in the maintenance of redox homeostasis by exchanging extracellular cystine in exchange for intracellular glutamate through the cystine-glutamate transporter (xCT/SLC7A11) was investigated in cancer ( Figure 1C ) ( 2 Generalities in glutamate receptors Glutamate receptors are divided into two main groups based on the mechanisms involved in the reception of the signals from glutaminergic neurons and the mechanism by which they relay their signal: the metabotropic glutamate receptors (mGluRs) and the ionotropic glutamate receptors (iGluRs) ( 2.1 Metabotropic glutamate receptors (mGluRs) Metabotropic glutamate receptors belong to the family C G-protein-coupled receptors (GPCR), the largest and most diverse group of membrane receptors in eukaryotes ( Group I comprised mGluR1 and mGluR5, which are coupled to phospholipase C (PLC) ( 2.2 Ionotropic glutamate receptors (iGluRs) The iGluRs are ligand-gated cation channels