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The mechanisms of lipotoxicity involve several cellular processes, such as ER stress, mitochondrial dysfunction and lysosomal permeabilization, ultimately leading to cell death (apoptosis, necroptosis or pyroptosis)

En estudios de cultivo celular, el tratamiento con Epithalon activa la telomerasa en fibroblastos fetales humanos, extendiendo su vida replicativa ms all del lmite de Hayflick normal el nmero mximo de veces que una clula humana normal puede dividirse

doi: 10.1177/2042018815577039

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The GSE146096 dataset containing transcriptomic profiles of lapatinib-exposed human cardiomyocytes was analyzed to identify ferroptosis-related differentially expressed genes (DEGs)