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The finding shifted understanding of how mitochondria communicate beyond energy production, signaling through circulating peptides that reach distant tissues

Experimental studies carried out during many years have revealed several biological mechanisms that deserve to be researched, such as angiogenesis, connective tissues, digestive system physiology, cell migration and signaling pathways

In organotypic hippocampal slice cultures, Dihexa and Nle-AngIV similarly augmented spinogenesis, with control slices showing 7 spines per 50-m dendrite length, compared to 11 for both Dihexa and Nle-AngIV treated slices [1]