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Horm Metab Res (2018) 50:7916

IGF-IR has also been found on human, pig, and rat Leydig cells[119121], where it enhances the differentiated functions of Leydig cells[122, 123]

For those with chronic conditions like IBD or EPI, ongoing management of the underlying disease is necessary, and periodic B12 monitoring may be recommended to ensure levels remain adequate