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This portal zonation reinforced the hypothesis that GSTP1/P2 could contribute to liver regeneration as hepatocyte proliferation begins in the periportal areas 30 and that gene inductions linked to cell proliferation mainly occurs in these areas

Part 2 further determined the safety, tolerability, efficacy, PK, and PD of the selected monotherapy dose in various malignant tumors, including AML/MDS, SCLC, myelofibrosis, ewing sarcoma, and poorly differentiated neuroendocrine tumors

Superoxide dismutase (SOD) and catalase are major antioxidant enzymes that catalyze ROS in most cells

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