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E.FeijenJ.et al (2006)

Young males displayed also higher NADP + /NADPH ratio in frozen blood compared to age-matched females, while NADH and GSSG were higher and GSH/GSSG ratio lower in 31-40 years old males compared to females (Supplementary figure 2i-s)

Some researchers believe mitochondrial dysfunction in children could be one of the many contributing factors , while others think it may be a result of other imbalances