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Exposure to copper nanoparticles (CuNPs) can induce oxidative stress in the kidney

Glia serve as a major supplier of cysteine for neuronal glutathione synthesis, and 50-60% of glutamate neurotransmitter is derived from the glutamine-glutamate shuttle between neurons and glia, with substantially smaller amounts of glutamate transmitter derived from glycolysis (12-14)

Aside from declining with age, reduced glutathione can also be caused by stress, poor nutrition, and exposure to certain toxins

Age related changes in the dermal mast cells and the associated changes in the dermal collagen and cells: A histological and electron microscopy study

10.1111/j.1476-5381.2010.01022.x 116 LinR.PiaoM.SongY