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Snoring/gasping/choking sounds while sleeping Pauses in breathing while sleeping Intermittent waking and insomnia Nocturia (frequent waking to use the restroom) Daytime sleepiness or fatigue Dry mouth, sore threat, or headache upon waking Difficulty concentrating or remembering things Irritability or depression Sexual dysfunction Refer to the STOP-BANG questionnaire in the Screening section of this protocol What are Conventional Medical Treatments for Sleep Apnea

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Remyelination involves the distinct stages of progenitor activation, recruitment (proliferation and migration) and differentiation into mature myelin-sheath-forming oligodendrocytes: each is orchestrated by a complex network of cells and signalling molecules