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Kang KA, Piao MJ, Hyun YJ, Zhen AX, Cho SJ, Ahn MJ et al (2019) Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells

doi: 10.1053/j.gastro.2010.08.049 90 Danneskiold-SamseNBAndersenDRadulescuIDNormann-HansenABrejnrodAKraghMet al

third, NAD + treatment can increase both the Nrf2 mRNA level and nuclear Nrf2 levels

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Initial stratification should integrate pre-treatment tumor genomics/epigenetics with host parameters to construct predictive models, and then longitudinal monitoring of tumor evolution under therapeutic pressure enables adaptive treatment adjustments