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It was found that at pre-symptomatic stage (150 days), BI1 downregulated most genes except Pnpla2 , while post-onset (180 days) all targets were downregulated (Supplementary Fig

SalicKGartESeidelFVerschurenLCaspersMvan DuyvenvoordeWet al

(3) Prospective cohort studies: large-scale, multicenter prospective cohorts are needed to longitudinally track microbiota changes and their relationship with DKD progression

The injury procedure involved laminectomy (level L2-L3) and a 60-s compression (neurosurgical piston (6066 g) of the exposed dural sac of the sacrocaudal spinal cord)