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Sonmez Ozkarakaya et al., 2021)

Pfizer and OPKO did not state the reasons for the initial denial

Mbio 8 , e0117917 (2017)

depend on GSH for their functioning and it is the only antioxidant that does not become a free radical by itself once it donates a free electron [3]

3D clonogenic assays demonstrated that the isogenic PSPH amp and PSPH V116I GBM 1919 cells display high sensitivity to the combination therapy under physiologically relevant low concentrations of glucose, a response that was not significantly observed in wildtype 1919 GBM cells (Fig