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Because these compounds are naturally occurring peptides with restricted patentability, opportunities for intellectual property protection and industry-sponsored development are limitedposing substantial barriers to the resource-intensive clinical investigations required to confirm therapeutic efficacy and long-term safety

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The final structures were validated using MolProbity 102 and the PDB validation server ( Residues with poor rotamer conformations and Ramachandran outliers were corrected in Coot

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