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Literature search was conducted on PubMed, Scopus, Web of Science, and Embase using a combination of the keywords gut microbiota, gut microbiome, gut-brain axis, gut-kidney axis, gut-brain-kidney axis, chronic kidney disease, dysbiosis, therapy, metabolites, and neuroinflammation. Relevant studies were selected and synthesized in this narrative review

More broadly, it underscores a key principle in neuromodulationwhen brain stimulation changes both symptoms and circuits, it moves from hopeful therapy to mechanistic medicine

Saturated fatty acids induce NLRP3 activation in human macrophages through K + efflux resulting from phospholipid saturation and Na, K-ATPase disruption

Hwang J, (and colleagues)

and FENa mean fractional excretion of sodium and FEK mean fractional excretion of potassium