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Retatrutide: Complication Focus TRIUMPH-4: Obesity + knee osteoarthritis (445 participants) TRIUMPH-2: Obesity + type 2 diabetes TRIUMPH-6: Weight maintenance trial Advantage: Multiple complication-specific trials could lead to broader label (obesity + OA + OSA indications)

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[47] The ability of vitamin A to increase tumor response to radiation while reducing toxicity has been theorized to be due to the stimulation of immune response to tumor tissue

However, MM is still incurable for the majority of patients who become refractory to treatment and ultimately relapse, thus further development of new therapeutic agents is warranted, such as specific inhibitors targeting activated oncogenes