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Its therapeutic value is primarily demonstrated in two aspects: significantly improving dyskinetic symptoms, and effectively prolonging "on" time while shortening "off" time

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Regional brain blood flow in man during acute changes in arterial blood gases

however, T-cells can alter their phenotype for increased expression of cell adhesion molecules, chemokine and cytokine receptors, and matrix-degrading enzymes for BBB attachment-gaining entrance ( via AHR, SCFAs, and the FFAR2 receptor, respectively, for modulating maturation, function, and inflammation (Rothhammer et al., 2016, 2018

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