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Similar content being viewed by others Introduction Lung cancer (LCA) ranks fifth for both men and women in Egypt and is the second most common cancer globally, as well as ranking 1st and 4th among the top cancer-related deaths worldwide and Egypt respectively

Former catalyzes the conversion of reduced glutathione (GSH) to its oxidized form (GSSG) and the latter enzyme regenerates the reduced form

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PhoA accumulation was analyzed by SDS-PAGE (NuPAGE 4 bis 12 %, Bis-Tris, Invitrogen, Waltham, MA, USA) and Western blot analyses were carried out using nitrocellulose membranes in the iBLOT2 system (Invitrogen, Waltham, MA, USA), both according to the supplier

However, the most common presentation of CP-induced nephrotoxicity is acute kidney injury (AKI) (Miller et al., 2010), which is characterized by the rapid decline of renal excretory function leading to the accumulation of nitrogenous waste products, water, and electrolytes (Ostermann and Joannidis, 2016