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Liposomal formulations, PEG-PLGA nanoparticles, and dendrimer or polymer micelles have each prolonged plasma half-life and shielded riboflavin from rapid renal loss, while surface ligandssuch as wheat-germ agglutinin, transferrin-mimic peptides, and BBB-shuttling sequencesenable active transcytosis across the bloodbrain barrier (8689)

Nature 334 , 706708 (1988)

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