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However, despite all these differences there is still a biological plausibility of a link between B 12 and depression given that B 12 is a necessary co-factor for methionine synthesis which provides methionine, the precursor of S-adenosylmethionine that is then needed for the formation of important brain neurotransmitters such as dopamine and norepinephrine (Reference Bailey, Stover and McNulty18,Reference Bottiglieri and Reynolds19)

Methylcobalamin is the most active and best absorbed form of Vitamin B12

We agree with the commenter's request to assign CPT code 0991T (X432T) to APC 5376 (Level 6 Urology and Related Services)

Setting Expectations for Treatment Patients considering this combination should have reasonable expectations

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