These findings align with preclinical data showing that circadian disruption enhances TNBC tumor growth and impairs the time-dependent efficacy of cisplatin therapy, suggesting that both intact circadian signaling and melatonin rhythms are crucial for optimizing chemotherapeutic outcomes 58
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Initially used to treat systemic iron overload, iron chelators have subsequently been found to exert neuroprotective effects and cross the bloodbrain barrier [174, 175]
These molecules modulate gene expression at transcriptional and post-transcriptional levels, influencing inflammation, oxidative stress, and neuronal repair
But chronically inconsistent technique can create a pattern of variable absorption that mimics dose inadequacy or treatment resistance
