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Because warfarin antagonizes GAS6-mediated activation, low dose Warfarin therapy during pregnancy may reduce pregnancy-associated breast cancer progression

53 Following activation, the former competitively inhibits molecules that stimulate drug resistance, while the nitrogen-mustard segment induces apoptotic activity by influencing the activities of MAPK, p38 kinase, JNK, MKK4, and caspase 3

Inflammatory cytokines may also promote ROS generation, which further reduces NO bioavailability by accelerating NO degradation and increasing oxidative stress (106)

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