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8, Unit 8.12

Switching to tirzepatide or a GLP-1/GIP combination may be more effective because it resets receptor sensitivity using a different chemical pathway

Neuronal autophagic deficits have been implicated in PD, with SNpc samples showing that PD neurons have increased autophagic degeneration including vacuolation of the endoplasmic reticulum and increased lysosome-like vacuoles [134]