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The mechanism works through beta-3 adrenergic receptors, which are concentrated in fat tissue, particularly around the abdomen and midsection

The very short cytoplasmic tail of CD38 allows for flexible movement within the cell membrane

The rodent studies typically use dosages equivalent to roughly 110 mcg/kg of body weight when allometrically scaled to humans, which puts a 200 lb person right in that 200500 mcg sweet spot