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LOCF-based placebo-adjusted weight-loss estimations can consequently be interpreted in one of two ways depending on whether LOCF values are used only to impute missing data, or if they are used to impute missing data and replace off-treatment values

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Subsequently, we used limited proteolysis to identify the regions of the polypeptide chain mostly prone to proteolysis and thus the sites of high flexibility or local unfolding 22 (Fig

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