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In many cases they possess an N-terminal signal peptide mediating correct subcellular sorting and trafficking and an anionic propeptide which is thought to be the major contributing factor inhibiting the antimicrobial activity by neutralizing the net positive charge of the mature peptide [19, 20]

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As an alternative chemotherapeutic agent, AMPs/ACPs display several extraordinary properties such as broad spectrum activity, high specificity, rapid mode of action, efficient tumor penetration due to small size, good solubility, low toxicity, ability to bypass the multidrug-resistance mechanism induced by tumor cells against conventional chemotherapy drugs and finally capability to produce in commercially available scale and make AMPs/ACPs as suitable candidates for the development of novel anticancer agents