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Description

The mouse research that established its mechanism and preclinical effects used subcutaneous injection at a fixed research dose (20 mg/kg, three times daily) a research-animal protocol, not a human administration guide

[PMC free article: PMC3757949] [PubMed: 23142820] 159

This selectivity defines the fragment's pharmacological niche

Indeed, such analysis is affected by clustering of the points on the surface, which changes from dataset to dataset and is irrelevant for the overall dependence of Hb on B 12