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The mechanisms by which IGF-I reverses and/or prevents microvascular rarefaction and improves tissue blood supply are likely multifaceted, and may involve, among others: 1) Apoptosis, since IGF-I inhibits oxidative stress-induced apoptosis by preserving the functional integrity of the mitochondria[56, 290]

Liver Int 2011, 31 (9), 13151324

Supplemental Tables S2S3)

According to this mechanism, the H 2 O 2 molecules initially absorb onto the Pt atom (step i), forming the activated state *H 2 O 2 (step ii)

Occasionally, individuals experience temporary minor discomfort or sensitivity at injury sites during early treatment