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Body weight was recorded at baseline and on days 5, 8 and 15 and the treatment dose was adjusted based on recent body weights recorded during the treatment period (Fig 2) Using the same study protocol, data involving the CON group has been previously published [10]

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If there is any basis in fact for my thoughts id be interested to know as i havent really done any research on this

The Lancet Gastroenterology and Hepatology , 1 (3), 226237

That these manipulations cause ER stressor, more specifically, induce the UPRand alter the ER redox environment implies that they do so by affecting the folding, maturation, and secretion of proteins transiting through the ER, but such an effect has not yet been directly demonstrated