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DNA Synthesis Vitamin B12 is necessary for adequately synthesizing DNA, the genetic material in all cells

Cell Death Discovery (2021) 7:113

The brain uses approximately one-fifth of the bodys total oxygen demand, so lots of free radicals are produced during metabolism in the brain, making glutathiones antioxidant services are especially crucial for preventing diseases like Parkinsons and Alzheimers

Furthermore, the redox activity of PDI, but not its chaperone function, rescued motor dysfunction and axonopathy in zebrafish models of ALS expressing mutant SOD1, together implying that PDI has an important role both in vitro and in vivo (Parakh et al., 2020)