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(2012) characterized GHK-Cus effects on over 4,000 human genes using microarray analysis, demonstrating broad modulation of tissue remodeling, antioxidant, and growth factor pathways [1]

In addition, the pain information transmission caused by the original peripheral nerve injury is out of balance when the expression of opioid receptors is downregulated in DRGs, resulting in the inability of endogenous opioid peptides to act on the receptor and leading to peripheral sensitization, which is also an important mechanism for the formation of morphine tolerance that seems to indicate that subcutaneous morphine injection in NP patients is difficult to modify to achieve better efficacy [77,81,105,108,128]