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Notably, such lesions are not randomly dispersed across the genome in mature spermatozoa but rather are targeted, with chromosome 15 being particularly susceptible to oxidative stress (142)

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Eventually, the activated effector caspases will cleave a large number of cellular substrates, leading to typical apoptotic phenotypes: chromatin condensation, DNA fragmentation, cell shrinkage, and membrane blebbing [37]

This result was also confirmed at the mRNA level quantified by qRT-PCR (Figure 5A, right)

Which is the ideal JAK inhibitor for alopecia areata - baricitinib, tofacitinib, ritlecitinib or ifidancitinib - revisiting the immunomechanisms of the JAK pathway