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Pathways The enzyme is deeply integrated into the pentose phosphate pathway which generates NADPH necessary for the reduction of glutathione disulfide

The major hallmarks, as described by Pavlova and Thompson (7), include: deregulated glucose and amino acid uptake, opportunistic ways of acquiring nutrients, use of metabolic intermediates for biomass and nicotinamide adenine dinucleotide phosphate (NADPH) synthesis, increased demand for nitrogen, and alterations in metabolite-driven gene expression and interaction with the microenvironment (7, 9)

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Here, we employed obligate cytosolic Rickettsia parkeri , which parasitizes over fifty host metabolites, to investigate bacterial utilization of host glutathione (GSH)

Aging is associated with a shift toward more pro-inflammatory oxylipin species, which may impair microvascular perfusion and attenuate anabolic responsiveness (96)