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Carnitine (L-carnitine) Complementary and Alternative Medicine Guide

doi: 10.1038/s41598-021-98612-6 55

ClarkeKTchabanenkoKPawloskyRCarterETodd KingMMusa-VelosoKet alKinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects

However, regularly new mutations and variants of unknown significance (VUS) are identified, requiring functional studies such as enzyme activity measurements or cellular flux analysis for confirmation of the diagnosis and characterization [51]