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Active inflammation also causes tissue hypoxia, which results from the concentration of inflammatory cells (including neutrophils, eosinophils, and monocytes), higher rates of cellular oxidative metabolism, and increased activity of various oxygen-consuming enzymes (119, 121)

Although clinical trials of EV-based therapy for AD remain limited, an early study in patients with mild-to-moderate AD suggested that adipose MSC-EVs were safe and potentially effective

PLE is also effective when used alongside topical hydroquinone, sunscreen, or laser therapies

Key Takeaways GHK-Cu degradation often occurs without visible discoloration

GHK-Cus copper-chelating activity and its role in endogenous tissue homeostasis have made it a research subject in multiple fields, including wound-healing biology, skin fibroblast pharmacology, and antioxidant pathway studies