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Earlier studies indicate that abnormal activation of the HGF/c-MET signaling pathway may hinder T-cell activation and growth, adversely affect DCs, and enhance the infiltration of immunosuppressive cells (M2-type TAMs, MDSCs, and Tregs), leading to reduced effectiveness of ICIs

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(2005).Classification of proliferative Hepatocellular lesions in Harlan Sprague-Dawley rats chronically exposed to dioxin-like compounds