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Since Nrf2 participates in the resolution of inflammation by repressing genes for proinflammatory cytokines IL-6 and IL-1 (Kobayashi et al., 2016

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It controls cell proliferation, stem cell renewal, and tissue regeneration across virtually every organ system

RESULTS Reduced protein-SSG is associated with decreased glutathione pools by CHAC1 induction in multiple cell types undergoing ferroptosis To investigate the pattern of protein-SSG in ferroptotic cells, we used the classical and commonly used ferroptosis inducer erastin because it can extensively induce ferroptosis in cells