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Almes M, Spraul A, Ruiz M, Girard M, Roquelaure B, Laborde N, Gottrand F, Turquet A, Lamireau T, Dabadie A, et al

While opioids activate brain chemistry related to pleasure and dependence by binding to mu-opioid receptors, acetaminophen primarily reduces pain by blocking cyclooxygenase (COX) enzymes in the brain and spinal cord