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As natural aging progresses, the overexpression and overactivation of MMP-1 disrupts the balance between collagen synthesis and degradation, driving a net loss of dermal collagen and progressive weakening of the extracellular matrix (ECM) [7, 8]

At the microbiota level, NAFLD patients, compared with controls, showed an increased abundance of Proteobacteria, Enterobacteriaceae, and Escherichia spp

However, most patients can live normally with the condition if its treated in its early stages

Cancer 10 , 319331 (2010)