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doi: 10.1056/NEJM196310102691501 49 Ouled-HaddouH.MessaoudiK.DemontY.SantosR

In addition, JHU083, an inhibitor of glutamine metabolism, has been observed to increase CD8 T cell and CD4 Th1 cell infiltration, thereby enhancing the efficacy of PD-1 blockers

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Despite their effectiveness, the long-term use of TCS is limited by a number of well-documented drawbacks