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However, the current evidence base is largely preclinical, and no large-scale human clinical trials have confirmed its efficacy

This distinction matters because it means the therapy works with your body's natural hormonal rhythm rather than overriding it

Psychol Med (2008) 38:77185.10.1017/S0033291707001675 13 MonksPJThompsonJMBullmoreETSucklingJBrammerMJWilliamsSCet alA functional MRI study of working memory task in euthymic bipolar disorder: evidence for task-specific dysfunction

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Despite its importance, vitamin B12 deficiency is surprisingly common, particularly in the UK, where it affects around 6% of people under 60 and up to 20% of those over 60