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This finding supports our hypothesis that NRF2 plays a protective role in the development of psoriasis and that SFN acts via NRF2-related pathways

For example, C-terminal amides and cyclic imides are targeted by the Cullin-RING ligases FBXO31 and CRBN, respectively 28,29

However, findings in a systematic review and meta-analysis of prolonged NSAID use (ranging from one to seven years) indicated NSAIDs accelerate OA progression