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They achieve this by modifying the biophysical properties of neuronal and glial cell membranes, suppressing pro-inflammatory mediators, fostering the resolution of inflammation, enhancing mitochondrial stability, and reducing reactive oxygen species (ROS) production (55)

The major drawback of both -LA and DHLA are their pro-oxidant effects which have been observed to occur under certain circumstances and result in the peroxidation of lipids

Lipid droplets accumulate in surviving HIV infected macrophages and associate with enlarged mitochondria Lipid dysregulation is a well-documented problem in the HIV infected population, and it is mostly associated with foam macrophages (uninfected and HIV infected) that survive for extended periods of time, resulting in increased risk for cardiovascular disease, atherosclerosis, and dementia 45,46,47,48

Although therapeutic monoclonal antibodies like cetuximab and tyrosine kinase inhibitors like lapatinib have not shown much success in clinical trials for TNBC patients, several EGFR-targeted antibody-drug conjugates (ADCs) show great potential for TNBC treatment and are currently undergoing clinical trials for TNBC patients 11

Disruption of the Rbm38-eIF4E complex with a synthetic peptide Pep8 increases p53 expression