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In contrast, in the brains of PD patients, this proportion increases dramatically, with pSer129 syn accounting for more than 90% of the protein localized within LBs [50, 51]

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Table 2 Genomic DATA 1.5 Polygenic risk scores (PRS) As discussed in previous sections, exome sequencing provides a deeper understanding of the genetic basis of complex disorders, since it enables a global analysis not only of pathogenic variants but also of risk variants, variants of uncertain significance (VUS), and benign variants