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I have found smaller doses (500mcg/injection) more frequently is right for me

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However, there are established patterns based on clinical observations

It's a relatively high amount for a supplement to have, but it shouldn't be a problem for most people since the maximum per-day allowance for adults is 400mcg.34 That said, you may want to avoid Doctor's Best Glutathione + Milk Thistle if you take another supplement that includes selenium or eat a lot of selenium-rich foods (e.g., Brazil nuts, tuna)