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Serum paraoxonaseactivities, nitric oxide, and malondialdehyde levels are altered in patientswith primary fibromyalgia syndrome

Sci Transl Med (2017) 9:eaak9679

Notably, some agents may possess nasal mucosa toxicity, thus, the toxicity evaluation is needed before intranasal administration

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4.4 Hepatoprotective effects 4.4.1 Protection against chemical - induced liver injury Liver damage caused by chemical exposure is a prevalent issue, frequently triggered by hepatotoxic substances like carbon tetrachloride (CCl4), acetaminophen, or alcohol