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In CIRS, inappropriate suppression of ADH relative to elevated osmolality suggests hypothalamic injury or receptor resistance, contributing to polydipsia, frequent urination, orthostatic intolerance, and salt wasting

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PMID 17826865

nicotinamide) reported delayed glucose clearance in cattle [15, 16], and rodent studies indicate that 500 mg/kg NR rescues fetal-placental growth via enhanced hepatic gluconeogenesis and glycemia [25]